New therapeutic medications and methods are urgently required for the treatment of Pulmonary Hypertension (PH), a deadly and chronic condition. The active ingredients of traditional Chinese medicine, Scutellaria baicalensis Georgi, baicalein and baicalin, have a variety of pharmacological effects. The use of baicalin and baicalein as a therapy for PH has been suggested by a number of research using in vitro and in vivo models of the disease. The anti-inflammatory response, inhibition of pulmonary smooth muscle cell proliferation and endothelial-to-mesenchymal transformation, stabilization of the extracellular matrix, and mitigation of oxidative stress are just a few of the potential mechanisms underlying the beneficial effects of baicalin and baicalein treatment on PH. These substances pharmacokinetics have also been examined. Baicalin and baicalein should continue to be researched as natural remedies because of their therapeutic potential.
