One of the most used cortical maps for research of human brain functions and in clinical practice is the Brodmann Area (BA) based map; nevertheless, little is known about the molecular structure of BAs. By examining 29 BAs, the current work produced a worldwide multiregional proteomic map of the human cerebral cortex. Based on commonalities in proteomic patterns, these 29 BAs were divided into six clusters: the motor and sensory cluster, the vision cluster, the auditory cluster and Broca's area, the Wernicke's area cluster, the cingulate cortex cluster, and the cluster for heterogeneous function.
