The body of a patient of schizophrenia was donated to the Medical College. During routine dissection a small anteriorly placed cavum septum pellucidum was observed along with fenestration of septum pellucidum posteriorly. Also, the lateral ventricles were dilated, foramen of Monro was absent and the fornix was caudally displaced. The article discusses the correlation between schizophrenia and septum pellucidum variations from point of view of embryological development as well as points to a possible infective or traumatic causation.