The COVID-19 pandemic resulted in a large increase in the number of cases of mucormycosis, an uncommon opportunistic fungal illness. The prevalence of mucormycosis was observed to be 2.1 times higher than usual in India during the first wave of COVID-19. During the second wave, however, these figures skyrocketed, with over 28,000 cases recorded. The link between C--OVID-19 and mucormycosis is mostly unknown. Among the several hypotheses offered were: a protracted uncontrolled hyperglycemic condition, glucocorticoid-induced immunosuppression, hyperglycemia, and lymphopenia, viral-induced lymphopenia and endothelitis, elevated blood free iron levels (hyper-ferritinemic condition), and ketonemia and ketoacidosis, even in the absence of diabetic mellitus.
